Phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate in dogs with naturally occurring malignant tumors
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منابع مشابه
Phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate in dogs with naturally occurring malignant tumors.
OBJECTIVE To conduct a phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate (HA-Pt) in dogs with naturally occurring malignant tumors. ANIMALS 18 healthy rats, 9 healthy mice, and 16 dogs with cancer. PROCEDURES HA-Pt was prepared and tested by inductively coupled plasma mass spectrometry; DNA-platinum adduct formation and antiproliferation effects of cisplatin and HA-Pt were compare...
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1Center for Orphan Drug Research, University of Minnesota, Minneapolis, MN, USA, 2 Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA, 3 College of Science and Engineering, University of Minnesota, Minneapolis, MN, USA, 4 UMP MINCEP Epilepsy Care, Minneapolis, MN, USA, 5 Mayo Clinic, Rochester, MN, USA, 6 College of Veterinar...
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ژورنال
عنوان ژورنال: American Journal of Veterinary Research
سال: 2016
ISSN: 0002-9645
DOI: 10.2460/ajvr.77.9.1005